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one gene-one enzyme hypothesisEin-Gen-ein-Enzym-Konzept (ger.)

  • The hypothesis that a large class of genes exists in which each gene controls the synthesis or activity of but a single enzyme. (Oxford Dict. of Genetics 2007)

    Each of these thousands of gene types has, in general, a unique specificity. This means that a given enzyme will usually have its final specificity set by one and only one gene. […] It is implied by Lindegren et al. that only one enzyme is concerned, an interpretation at variance with the one-gene-one-enzyme concept, at least in its simplest form.

    Beadle, G.W. (1945). Biochemical genetics. Chem. Rev. 37, 15-96: 19; 63.

    one gene-one enzyme hypothesis
    Beadle, G.W. (1951). Chemical genetics. In: Dunn, L.C. (ed.). Genetics in the Twentieth Century, 221-239: 228.